Structural knowledge of broadly neutralizing antibodies against HIV-1 guides the design of an immunogen to elicit them. Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors The massless charge carriers in graphene interact with highly charged defects to create an analog of atomic collapse states. Observing Atomic Collapse Resonances in Artificial Nuclei on Graphene Szech Marketplace interactions affect how much people are willing to pay to prolong the life of a mouse. This Week in Science Editors’ Choice Science Staff New Products Science CareersĪ. Image: Christina Corbaci, Adam Gardner, Joe Jardine, Sergey Menis, and William Schief, The Scripps Research Institute
This work has promising implications for HIV vaccine research. The immunogen is a virus-like nanoparticle, ~30 nanometers in diameter, displaying 60 copies of an HIV gp120 outer domain protein engineered to bind germline precursors of specific broadly neutralizing antibodies. NextGenVOICES TECHNICAL COMMENT ABSTRACTSĬOVER Model of a candidate HIV vaccine prime immunogen (center) engaging germline B cell receptors (bottom) to initiate an antibody immune response. > Find More Online Check out Science Express, our podcast, videos, daily news, our research journals, and Science Careers at Unpalatable Politics > Science Express Read articles on the formation of cirrus clouds, the evolution of Arctic polar climate, and the common origin of water on Earth and the Moon. How Big a Role Should Neonicotinoids Play in Food Security?Ĭhina Heads Off Deadly Blood Disorder Insistence on Gathering Real Data Confirms Low Radiation Exposuresīacterial Subversion of Host Innate Immune PathwaysĬellular Self-Defense: How Cell-Autonomous Immunity Protects Against PathogensĬONTENTS continued > ON THE WEB THIS WEEK Pesticides Under Fire for Risks to Pollinators Proposed Change in Awarding Grants at NSF Spurs Partisan Sniping Boston Bombing Victims Aided by Biologist-SurgeonĪmid Heightened Concerns, New Name for Novel Coronavirus Emerges
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